In general, when men start hormone replacement or optimization therapy, they tend to stay on it. However, it may not be required that you stay on it in perpetuity. While the effects of HRT/TRT will diminish after you stop treatment, it may be considered safe to stop if you have regained sufficient muscle mass, maintained lower body fat, and adopted a healthy lifestyle regimen (optimal diet, resistance training, rest). Under the supervision of your doctor, depending on your age, health, and final lab results, some males can maintain optimum hormone levels without the need for ongoing optimization therapy.