WHAT IS KISSPEPTIN?
Kisspeptin, made in the hypothalamus, is an important hormone that releases several other hormones. Also called metastin, this interesting hormone is connected to puberty and may also help stop the spread of cancer. Kisspeptins are a family of proteins that are essential for fertility.
The first gene member of the family was discovered in 1996 by a group working in Hershey, Pennsylvania. It is named after the city’s chocolate ‘Kisses,’ which are made in Hershey.
Kisspeptin has a non-hormonal role and was initially named metastin after its ability to prevent the spread of cancer (metastasis).
WHAT DOES KISSPEPTIN DO?
Kisspeptin enters into receptor sites in the pituitary gland, starting a reaction that causes the gland to release neurotransmitters. Those neurotransmitters then signal the release of luteinizing hormone and follicle-stimulating hormone. These hormones have a role to play in the production of testosterone and oestradiol. Without Kisspeptin, this entire chain reaction would be damaged.
HOW DOES KISSPEPTIN WORK?
Kisspeptin has a secondary function that is not related to hormones. Its original name, metastin, points to its ability to prevent the spread of cancer in the body. Kisspeptin is released in conjunction with two other hormones: dynorphin and neurokinin B.
WHAT ARE THE BENEFITS OF KISSPEPTIN?
Recent data suggest that Kisspeptin may play a role in food intake, glucose homeostasis, and mediating energy balance on reproductive function. Thus, Kisspeptin may directly regulate energy balance and may also be a direct regulator of metabolism.
WHAT ARE THE POTENTIAL CLINIC USES FOR KISSPEPTIN PEPTIDE THERAPY?
Potential clinical uses of kisspeptin include but are not limited to:
- the treatment of delayed or precocious puberty
- downregulation of sex steroids in the treatment of sex steroid-dependent tumors
- treatment of metastatic cancers.